RPH-2823

SKU: orb1706080

Description

RPH-2823 is a basic derivative of amphotericin that functions as a diuretic and natriuretic agent while conserving potassium. It demonstrates dose-dependent effects by reducing short-circuit current and elevating transepithelial resistance in epithelial models. This profile supports its research use in studying renal physiology and ion transport mechanisms in both in vitro and in vivo settings.

Key Properties

• CAS Number: 96558-24-6
• MW: 370.41
• Purity: 99.67%
• Formula: C₁₇H₂₂N₈O₂
• SMILES: OC(COC1=CC=C(C=C1)C=2N=C3C(N=C(N=C3N)N)=NC2N)CN(C)C
• Target: Others

Bioactivity

• In Vivo:
  Avoiding the kaliuresis of 25 mumol/kg furosemide in male Wistar rats, RPH 2823 (2.5 mumol/kg) demonstrates its efficacy. RPH 2823 (1 mg/kg and 5 mg/kg, i.v.) exhibits a terminal elimination half-life of 3 h, with approximately 47% of the administered dose being excreted unchanged in the urine.
• In Vitro:
  Interacting with the Na+ channel or a regulator site within the apical membrane, RPH-2823 influences transepithelial Na+ transport.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RPH 2823, RPH2823, RPH-2823

Compound Identifiers

PubChem CID

125984