Ro 90-7501

SKU: orb1706703

Description

Ro 90-7501

Research Area

Cell Biology, Metabolism Research, Molecular Biology, Neuroscience, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 293762-45-5
• MW: 340.38
• Purity: 97.19% (May vary between batches)
• Formula: C₂₀H₁₆N₆
• SMILES: NC1=CC=C(C=C1)C1=NC2=C(N1)C=C(C=C2)C1=NC2=C(N1)C=C(N)C=C2
• Target: Beta Amyloid,ATM/ATR,Phosphatase,Gamma-secretase,Apoptosis
• Solubility: 10% DMSO+90% Saline:2 mg/mL (5.88 mM);DMSO:30 mg/mL (88.14 mM)

Bioactivity

• In Vivo:
  Treatment with Ro 90-7501 (5 μg/g; intraperitoneal injection; daily; continuous for 21 days; female BALB/c nude mice) significantly delays tumor growth and markedly reduces tumor volume.
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• In Vitro:
  Compared to control HeLa and ME-180 cells, Ro 90-7501 significantly enhances radiation sensitivity. Following irradiation, Ro 90-7501 markedly increases apoptosis and impairs the cell cycle. Post-irradiation, Ro 90-7501 suppresses the phosphorylation of ATM and its downstream proteins, such as H2AX, Chk1, and Chk2. RO 90-7501 itself does not affect IFN-β and NFκB promoter activity but significantly enhances poly I:C-induced IFN-β promoter activation and dose-dependently inhibits NF-κB activation. Treatment with RO 90-7501 significantly enhances the antiviral activity of poly I:C.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Amyloid β42, Apoptosis, ATR, ATM, Gammasecretase, PP5, Protein phosphatase 5, Ro 90 7501, Ro 907501, Ro 90-7501, RO-90-7501, γ secretase(Aβ42)

Compound Identifiers

PubChem CID

824226