Ro 8-4304 Hydrochloride

SKU: orb1220137

Description

Ro 8-4304 Hydrochloride is an antagonist of NMDA receptor with IC50 of 0.4 μM Ro 8-4304 is a voltage-independent, non-competitive antagonist of NMDA receptors in rat cultured cortical neurones and exhibits a state-dependent mode of action similar to that described for ifenprodil. The apparent affinity of Ro 8-4304 for the NMDA receptor increased in an NMDA concentration-dependent manner so that Ro 8-4304 inhibited 10 and 100 microM NMDA responses with IC50s of 2.3 and 0.36 microM, respectively. Currents elicited by 1 microM NMDA were slightly potentiated in the presence of 10 microM Ro 8-4304, and Ro 8-4304 binding slowed the rate of glutamate dissociation from NMDA receptors.

Key Properties

• CAS Number: 195988-65-9
• MW: 406.9
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₄ClFN₂O₃?
• SMILES: NC(=O)c1ccc(OCC(O)CN2CCC(=CC2)c2ccc(F)cc2)cc1
• Target: NMDAR

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NMDAR