Ro 5212773

SKU: orb1298155

Description

Ro 5212773

Key Properties

• CAS Number: 1110781-88-8
• MW: 378.39
• Purity: 99.61%
• Formula: C₂₀H₂₁F₃N₂O₂
• SMILES: CCOc1cccc(NC(=O)c2ccc(N3CCCC3)c(c2)C(F)(F)F)c1
• Target: Others
• Solubility: 10% DMSO+90% Corn Oil:2.5 mg/mL (6.61 mM);DMSO:55 mg/mL (145.35 mM)

Bioactivity

• Target IC50:
  TAAR1:28 nM
• In Vivo:
  EPPTB prevents the reduction of the firing frequency of DA neurons induced by p-tyramine (p-tyr), a nonselective TAAR1 agonist. the EPPTB effects were absent in Taar1 knockout mice, ruling out off-target effects.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

amine-associated receptor 1 (TAAR2), Epptb, GPCR, neuronal, mesolimbic, Inhibitor, inhibit, Ro 5212773, Ro5212773, Ro-5212773, TAAR1, system

Compound Identifiers

PubChem CID

25175634