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RO 46-8443

SKU: orb1223235

Description

RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. The observed parallel rightward shift of concentration-response curves with different antagonist concentrations is consistent with a competitive binding mode. Since R0 46-8443 selectively inhibits ETB receptor mediated responses, it is a valuable tool for clarifying the role of ETB receptors in pathology.

Images & Validation

Key Properties

CAS Number175556-12-4
MW609.69
Purity>98% (HPLC)
FormulaC31H35N3O8S
SMILESc1(ccc(cc1)C(C)(C)C)S(=O)(=O)Nc1nc(nc(c1Oc1c(cccc1)OC)OC[C@@H](CO)O)c1ccc(cc1)OC
TargetEGFR
SolubilityIn Vitro: DMSO : 250 mg/mL (410.04 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

RO 46-8443 | RO46-8443 | RO-46-8443 | RO 468443

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  • RO 46-8443 [orb1304169]

    98.50% (May vary between batches)

    175556-12-4

    609.69

    C31H35N3O8S

    2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
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Protocol Information

RO 46-8443 (orb1223235)

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% DMSO +
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Available Sizes

Select a size below

2 mg
$ 90.00
5 mg
$ 130.00
10 mg
$ 200.00
25 mg
$ 390.00
50 mg
$ 540.00
100 mg
$ 780.00
500 mg
$ 1,640.00