RN9893

SKU: orb1699515

Description

RN9893 is a potent and selective TRPV4 channel antagonist, exhibiting IC50 values of 320 nM (mouse), 420 nM (human), and 660 nM (rat). It is a valuable research tool for investigating TRPV4's role in pain, pulmonary edema, and skeletal dysplasia in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1803003-68-0
• MW: 500.49
• Purity: 99.89% (May vary between batches)
• Formula: C₂₁H₂₃F₃N₄O₅S
• SMILES: C(NC1=CC=C(S(=O)(=O)N2CCN(C(C)C)CC2)C=C1)(=O)C3=C(N(=O)=O)C=C(C(F)(F)F)C=C3
• Target: TRP/TRPV Channel
• Solubility: DMSO:200 mg/mL (399.61 mM)

Bioactivity

• Target IC50:
  TRPV4 (rat):660 nM|TRPV4 (human):420 nM|TRPV4 (mouse):320 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RN9893, RN-9893, RN 9893, RN 9893 Hydrochloride, TRPV4, TRPVChannel, TRPV Channel, TRPChannel, TRP Channel

Compound Identifiers

PubChem CID

121513880