RK-9123016

SKU: orb1304926

Description

RK-9123016

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 955900-27-3
• MW: 374.42
• Purity: 100.00% (May vary between batches)
• Formula: C₁₆H₁₈N₆O₃S
• SMILES: C(C1=C(OC)C=CC(C=NNC(NCC=C)=S)=C1)N2C=C(N(=O)=O)C=N2
• Target: Sirtuin
• Solubility: DMSO:3.75 mg/mL (10.02 mM)

Bioactivity

• Target IC50:
  SIRT2:0.18 μM
• In Vitro:
  RK-9123016 inhibited the enzymatic activity of SIRT2 with an IC50 value of 0.18 µM but not other human sirtuin members including SIRT1 and SIRT3 at 100 µM in vitro electrophoretic mobility shift assay. RK-9123016 inhibited the SIRT2 activity in MCF-7 cells by concentration dependent manner (0-30 µM).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RK9123016, RK-9123016, RK 9123016, SIRT2

Compound Identifiers

PubChem CID

1856434