RIPK1-IN-7

SKU: orb1309159

Description

RIPK1-IN-7 is a highly potent and selective RIPK1 inhibitor with a Kd of 4 nM and an enzymatic IC50 of 11 nM. It demonstrates significant antimetastatic efficacy in vivo, as shown in a B16 melanoma lung metastasis model, making it a valuable tool for researching necroptosis and inflammatory diseases.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2300982-44-7
• MW: 481.47
• Purity: 98.18% (May vary between batches)
• Formula: C₂₅H₂₂F₃N₅O₂
• SMILES: CCn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc12
• Target: RIP kinase
• Solubility: DMSO:60 mg/mL (124.62 mM);H2O:0.1 mg/mL (0.21 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.15 mM)

Bioactivity

• Target IC50:
  RIPK1:(kd)4 nM |RIPK1:11 nM
• In Vitro:
  In the TSZ-induced HT29 cell necroptosis model, RIPK1-IN-7 shows potent cell protection effect (EC50 of 2nM). RIPK1-IN-7 displays considerable activity against several other kinases(Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC50s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Axl, Flt4, HRI, Mer, Inhibitor, inhibit, Receptor-interacting protein kinases, RIPK, RIP kinase, RIPK1, RIPkinase, RIPK1 IN 7, RIPK1IN7, RIPK-1-IN-7, RIPK1-IN-7, TrkA, TrkC, TrkB

Compound Identifiers

PubChem CID

137321158