RG2833

SKU: orb1300594

Description

RG2833 (RGFP109) is a brain-penetrant histone deacetylase (HDAC) inhibitor with IC50 values of 60 nM for HDAC1 and 50 nM for HDAC3. It is a research tool used in vitro and in vivo for studying epigenetic mechanisms in neuroscience, including models of neurodegenerative and psychiatric disorders.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1215493-56-3
• MW: 339.43
• Purity: 99.50%
• Formula: C₂₀H₂₅N₃O₂
• SMILES: Cc1ccc(cc1)C(=O)NCCCCCC(=O)Nc1ccccc1N
• Target: HDAC
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.89 mM);DMSO:45 mg/mL (132.58 mM);Ethanol:10 mg/mL (29.46 mM)

Bioactivity

• Target IC50:
  HDAC1:32 nM(Ki)|HDAC1:60 nM|HDAC3:5 nM(Ki)|HDAC3:50 nM
• In Vitro:
  In unstimulated peripheral blood mononuclear cells, RG2833 upregulates the level of the synaptic mRNA and protein in a dose-dependent manner.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Histone deacetylases, HDAC1, HDAC3, HDAC, Inhibitor, RGFP 109, RGFP109, RGFP-109, RG 2833, RG2833, RG-2833

Compound Identifiers

PubChem CID

56654642