Resiquimod

• Catalog Number: orb1300307
• Category: Small Molecules
• Description: Resiquimod
• CAS Number: 144875-48-9
• Purity: 99.67%
• MW: 314.38
• SMILES: CCOCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O
• Formula: C₁₇H₂₂N₄O₂
• Biological Activity: Resiquimod (R848) is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect through the TLR signaling pathway by binding to and activating TLR7 and 8 mainly on dendritic cells, macrophages, and B-lymphocytes. This induces the nuclear translocation of the transcription activator NF-kB as well as activation of other transcription factors. This may lead to an increase in mRNA levels and subsequent production of cytokines, especially interferon-alpha (INF-a) and other cytokines, thereby enhancing T-helper 1 (Th1) immune responses. In addition, topical application of resiquimod appears to activate Langerhans' cells, leading to an enhanced activation of T-lymphocytes.
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.