Ravoxertinib

SKU: orb1300705

Description

Ravoxertinib

Research Area

Signal Transduction

Key Properties

• CAS Number: 1453848-26-4
• MW: 440.86
• Purity: 99.87% (May vary between batches)
• Formula: C₂₁H₁₈ClFN₆O₂
• SMILES: Cn1nccc1Nc1nccc(n1)-c1ccn([C@H](CO)c2ccc(Cl)c(F)c2)c(=O)c1
• Target: ERK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.54 mM);Ethanol:81 mg/mL (183.73 mM);DMSO:245 mg/mL (555.73 mM)

Bioactivity

• Target IC50:
  ERK1:1.1 nM|ERK2:0.3 nM|p-RSK:12 nM
• In Vivo:
  GDC-0994 (p.o.) inhibits intracellular ERK phosphorylation and activation of ERK-mediated signaling pathways, subsequently impeding the proliferation and survival of ERK-dependent tumor cells. In in vitro cancer models, GDC-0994 (p.o.) demonstrates significant single-dose efficacy, including against BRAF and KRAS mutant human xenograft tumors in mice.
• In Vitro:
  GDC-0994 significantly inhibits phospho-p90RSK in tumor cells.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ravoxertinib, inhibit, ERK1, ERK2, ERK, Extracellular signal regulated kinases, Inhibitor, GDC-0994, GDC0994, GDC 0994

Compound Identifiers

PubChem CID

71727581