Ramelteon

SKU: orb1225778

Description

Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse. (In Vivo):Ramelteon (p.o.; 0.1 and 1 mg/kg) accelerates reentrainment of running wheel activity rhythm to the new lightdark cycle.Ramelteon (p.o.; 3, 10, and 30 mg/kg) does not affect learning or memory in rats tested by the water maze task and the delayed match to position task, implying that MT1/MT2 receptor agonists have no abuse potential.Ramelteon (0.0001, 0.001, 0.01, and 0.1 mg/kg; p.o.; 8 hours) significantly decreases wakefulness at doses of 0.001, 0.01, and 0.1 mg/kg, increases slow-wave sleep at doses of 0.001, 0.01, and 0.1 mg/kg, and increases rapid eye movement sleep at a dose of 0.1 mg/kg.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 196597-26-9
• MW: 259.35
• Purity: >98% (HPLC)
• Formula: C₁₆H₂₁NO₂
• SMILES: CCC(=O)NCC[C@@H]1CCC2=C1C3=C(C=C2)OCC3
• Target: MMP
• Solubility: Ethanol: 52 mg/mL (200.5 mM); DMSO: 52 mg/mL (200.5 mM)

Bioactivity

• In Vivo:
  Ramelteon (p.o. ; 0.1 and 1 mg/kg) accelerates reentrainment of running wheel activity rhythm to the new lightdark cycle. Ramelteon (p.o. ; 3, 10, and 30 mg/kg) does not affect learning or memory in rats tested by the water maze task and the delayed match to position task, implying that MT1/MT2 receptor agonists have no abuse potential. Ramelteon (0.0001, 0.001, 0.01, and 0.1 mg/kg; p.o. ; 8 hours) significantly decreases wakefulness at doses of 0.001, 0.01, and 0.1 mg/kg, increases slow-wave sleep at doses of 0.001, 0.01, and 0.1 mg/kg, and increases rapid eye movement sleep at a dose of 0.1 mg/kg. Animal model: Male Wistar or Fischer 344 (F344) rats. Dosage: 0.1 and 1 mg/kg; 3, 10, and 30 mg/kg. Administration: p.o. Result: Accelerated reentrainment of running wheel activity rhythm to the new lightdark cycle. Ramelteon did not affect learning or memory in rats tested by the water maze task and the delayed match to position task, implying that MT1/MT2 receptor agonists have no abuse potential. Animal model: Adult cats (2.5-6.1 kg). Dosage: 0.0001, 0.001, 0.01, and 0.1 mg/kg. Administration: p.o. ; 8 hours. Result: Significantly decreased wakefulness at doses of 0.001, 0.01, and 0.1 mg/kg, increased slow-wave sleep at doses of 0.001, 0.01, and 0.1 mg/kg, and increased rapid eye movement sleep at a dose of 0.1 mg/kg.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TAK-375

Quick Database Links

Gene Symbol

MMP