Ramatroban

SKU: orb1305546

Description

Ramatroban (BAY u3405) is a thromboxane A2 (TxA2) receptor antagonist approved for allergic rhinitis. It has been investigated in clinical trials for asthma treatment and is utilized in preclinical research to study TxA2-mediated pathways in both in vitro and in vivo models of inflammation.

Research Area

Immunology & Inflammation, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 116649-85-5
• MW: 416.47
• Purity: 99.96%
• Formula: C₂₁H₂₁FN₂O₄S
• SMILES: C(CC(O)=O)N1C2=C(C=3C1=CC=CC3)C[C@H](NS(=O)(=O)C4=CC=C(F)C=C4)CC2
• Target: PPAR,GPCR,Prostaglandin Receptor
• Solubility: DMSO:50 mg/mL (120.06 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.8 mM);Ethanol:100 mM

Bioactivity

• Target IC50:
  CRTH2:113 nM|TXA2:14 nM|DP2 (human):33.4 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BAY u 3405, BAY u3405, BAY u-3405, CRTh2, Inhibitor, inhibit, Ramatroban, ProstaglandinReceptor, Prostaglandin Receptor, TXA2R

Compound Identifiers

PubChem CID

123879