Ragaglitazar

SKU: orb1699555

Description

Ragaglitazar

Research Area

Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 222834-30-2
• MW: 419.47
• Purity: 97.46% (May vary between batches)
• Formula: C₂₅H₂₅NO₅
• SMILES: C(COC1=CC=C(C[C@H](OCC)C(O)=O)C=C1)N2C=3C(OC=4C2=CC=CC4)=CC=CC3
• Target: PPAR
• Solubility: DMSO:50 mg/mL (119.2 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (5.96 mM)

Bioactivity

• In Vivo:
  METHODS: SD rats fed a high-fat diet were treated with Ragaglitazar (NNC-61-0029) (0.1, 0.3, 1, 10, 30 mg/kg) to observe the improvement of blood lipid levels in rats. RESULTS Rats showed a dose-dependent improvement in plasma lipid levels, and plasma Apo CIII levels were significantly reduced in ragaglitazar (10 mg/kg) (P<0.05).
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• In Vitro:
  METHODS: A comparative dose-response study of PPARγ and PPARα was performed using Ragaglitazar (NNC-61-0029) (0.1, 1, 10, 100 nM). RESULTS Ragaglitazar (NNC-61-0029) showed significant activation of both isoforms. Ragaglitazar showed weaker potency against PPARγ (EC50=324 nm) and more potent activation of PPARα (EC50=270 nm).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PPARα, PPARγ, Ragaglitazar, (-)-DRF-2725, DRF 2725, DRF2725, DRF-2725, NNC 61-0029, NNC-61-0029, NNC61-0029, NN 622, NN622, NN-622

Compound Identifiers

PubChem CID

447458