R306465

SKU: orb1705131

Description

R306465 (JNJ-16241199) is a potent and selective HDAC1 inhibitor (IC50 = 3.3 nM) that induces histone acetylation and apoptosis. It demonstrates broad-spectrum antitumor activity in preclinical studies, supporting its investigation for both solid tumors and hematological malignancies in vitro and in vivo.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 604769-01-9
• MW: 413.45
• Purity: 99.64% (May vary between batches)
• Formula: C₁₉H₁₉N₅O₄S
• SMILES: O=C(NO)C1=CN=C(N=C1)N2CCN(CC2)S(=O)(=O)C=3C=CC=4C=CC=CC4C3
• Target: Apoptosis,HDAC
• Solubility: DMSO:5 mg/mL (12.09 mM)

Bioactivity

• Target IC50:
  HDAC1:23 nM|HDAC1:3.3 nM
• In Vivo:
  b>METHODS: R306465 (10-40 mpk, oral) was administered subcutaneously to nude mice bearing A2780, H460, and HCT116 cell models, and tumor growth in nude mice was observed. RESULTS: R306465 inhibited tumor growth in the three nude mouse models.
• In Vitro:
  b>METHODS: A2780 cells were treated with R306465 (0.1, 0.3, 1 μM, 24-48 h), and FACS analysis was performed to analyze whether the antiproliferative effect in A2780 cells was attributed to the induction of cell cycle arrest or cell death. RESULTS: R306465 induced apoptosis of A2780 cells in a concentration-dependent manner and inhibited angiogenesis.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

R306465, R-306465, R 306465, JNJ16241199, JNJ-16241199, JNJ 16241199, HDAC1, Apoptosis

Compound Identifiers

PubChem CID

10309899