R162

SKU: orb1303091

Description

R162 is a potent and selective small molecule inhibitor of glutamate dehydrogenase 1 (GDH1). It is a valuable research tool for investigating glutamine metabolism in cancer biology and metabolic disorders, with utility in both in vitro enzymatic assays and cellular studies.

Research Area

Metabolism Research

Key Properties

• CAS Number: 64302-87-0
• MW: 264.28
• Purity: 98.15%
• Formula: C₁₇H₁₂O₃
• SMILES: Oc1c(CC=C)ccc2C(=O)c3ccccc3C(=O)c12
• Target: Dehydrogenase,Others
• Solubility: DMSO:3.85 mg/mL (14.57 mM)

Bioactivity

• In Vivo:
  In xenograft tumor mouse models, R162 (30 mg/kg/day, i.p.) does not cause a significant histopathological change between the vehicle-treated and R162-treated groups, nor alters complete blood counts, or hematopoietic properties. Compared with control mice, R162 (20 mg/kg/day) markedly decreases tumor growth and masses and effectively inhibits GDH1 activity in resected tumors from xenograft nude mice.
• In Vitro:
  R162 decreased intracellular fumarate levels attenuated GPx activity by inhibited GDH1 activity, increased ROS levels, and reduced cell proliferation in H1299 and MDA-MB231 cells. R162 inhibits tumor growth potential and cell proliferation of human cancer cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, glutamate dehydrogenase 1 (GDH1), R 162, R162, R-162

Compound Identifiers

PubChem CID

4412951