(R)-STU104-d6

SKU: orb3027757

Description

(R)-STU104-d6 is a deuterium-labeled variant of (R)-STU104. This compound acts as a potent and orally active inhibitor of the interaction between TAK1 and MKK3 proteins, exhibiting IC50 values of 0.58 μM for TNF-α and 4.0 μM for MKK3 phosphorylation. By binding to MKK3, (R)-STU104 hinders TAK1's ability to phosphorylate MKK3, thereby disrupting the TAK1/MKK3/p38/MnK1/MK2/elF4E signaling pathway. It is utilized in research related to ulcerative colitis.

Research Area

Signal Transduction

Key Properties

• CAS Number: 3063042-81-6
• MW: 304.37
• Formula: C₁₈H₁₈₂D₆O₄
• SMILES: O(C([2H])([2H])[2H])C1=C2[C@H](CC(=O)C2=CC(OC([2H])([2H])[2H])=C1)C3=CC=C(OC)C=C3
• Target: p38 MAPK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

p38 MAPK