(R)-Elexacaftor

SKU: orb2278784

Description

(R)-Elexacaftor (compound 37) is the enantiomer of Elexacaftor (compound 1). (R)-Elexacaftor is a CFTR modulator with an EC50 of 0.29 μM for CFTR dF508.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2229860-99-3
• MW: 597.65
• Purity: 98.99%
• Formula: C₂₆H₃₄F₃N₇O₄S
• SMILES: C(NS(=O)(=O)C1=CN(C)N=C1C)(=O)C2=C(N=C(C=C2)N3N=C(OCC(C(F)(F)F)(C)C)C=C3)N4C[C@H](C)CC4(C)C
• Target: CFTR
• Solubility: DMSO:80 mg/mL (133.86 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.52 mM)

Bioactivity

• Target IC50:
  F508del CFTR:0.29 uM (EC50)

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

2-O-Glucosyloxy-4-methoxycinnamic acid, Elexacaftor, VX 445, VX445, VX-445

Compound Identifiers

PubChem CID

134587287