R 59-022

SKU: orb1706743

Description

R 59-022

Research Area

Epigenetics & Chromatin, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 93076-89-2
• MW: 459.58
• Purity: 98.55%
• Formula: C₂₇H₂₆FN₃OS
• SMILES: O=C1C(=C(N=C2SC=CN21)C)CCN3CCC(=C(C=4C=CC=CC4)C5=CC=C(F)C=C5)CC3
• Target: PKC,5-HT Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.35 mM);DMSO:50 mg/mL (108.79 mM)

Bioactivity

• Target IC50:
  DGK:2.8 μM|EBOV GP:~2 µM
• In Vitro:
  Vero cells were treated with increasing concentrations of R 59-022 and exposed for 4 hours to MLV pseudotypes encoding LacZ and bearing EBOV GP or VSV-G in the presence of the drug. R 59-022 blocked an entry step specific to EBOV GP. Vero cells were treated with increasing concentrations of R 59-022 and exposed to VLPs bearing EBOV GP or VSV G in the presence of the drug for 3 h. By CCF2-AM staining and flow cytometry analysis, R 59-022 dose-dependent decrease in entry by the VLPs harboring the EBOV GP , IC50: ~2 µM.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

diacylglycerol kinase, Diacylglycerol kinase inhibitor I, DGK, DKGI-I, 5HTReceptor, 5HT Receptor, 5-HT Receptor, PKC, serotonin, R 59 022, R 59022, R 59-022

Compound Identifiers

PubChem CID

3012