R-1479

SKU: orb1679031

Description

R-1479 (4'-Azidocytidine) is a potent inhibitor of the HCV RNA-dependent RNA polymerase (RdRp), demonstrating an IC50 of 1.28 μM in a subgenomic replicon assay. This nucleoside analog is a valuable research tool for investigating HCV replication mechanisms and screening for antiviral agents in vitro.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 478182-28-4
• MW: 284.23
• Purity: 99.68% (May vary between batches)
• Formula: C₉H₁₂N₆O₅
• SMILES: Nc1ccn([C@@H]2O[C@@](CO)(N=[N+]=[N-])[C@@H](O)[C@H]2O)c(=O)n1
• Target: HCV Protease
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (11.61 mM);DMSO:90 mg/mL (316.64 mM)

Bioactivity

• Target IC50:
  HCV replication:1.28 μM
• In Vitro:
  R-1479 inhibits HCV RNA replication and reduces Renillaluciferase activity of proliferating replicon cells in a dose-dependent manner. R-1479 inhibits RNA synthesis mediated by NS5B with an IC50 value of 320 nM and the RNA polymerase encoded by HCV.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

4'-Azidocytidine, HCVProtease, HCV replicon, HCV Protease, R 1479, R1479, R-1479

Compound Identifiers

PubChem CID

457388