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Pyrimidinone 8

SKU: orb2945052

Description

Pyrimidinone 8 is a reversible, linear non-competitive inhibitor of human DMT1 (Ki=20 µM) that blocks cellular iron uptake (IC50=13.8 µM) without altering transporter surface expression or pH sensitivity. This tool compound is useful for in vitro studies of iron metabolism and metal transporter biology.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number65004-42-4
MW204.229
FormulaC10H12N4O
SMILESO=C1N=C(NC(=C1)C)N2N=C(C=C2C)C
TargetFerroportin

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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Pyrimidinone 8 (orb2945052)

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