Pterine-6-carboxylic acid

SKU: orb1679998

Description

Pterine-6-carboxylic acid is a photoproduct of folic acid degradation. It serves as a photosensitizer in research to investigate UVA-induced DNA damage mechanisms, applicable in both in vitro and cellular photobiology studies.

Research Area

Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 948-60-7
• MW: 207.15
• Purity: 98.00% (May vary between batches)
• Formula: C₇H₅N₅O₃
• SMILES: Nc1nc2ncc(nc2c(=O)[nH]1)C(O)=O
• Target: Others,PDE,DNA
• Solubility: DMSO:Slightly soluble

Bioactivity

• In Vitro:
  Pterin-6-carboxylic acid induces DNA photooxidation specifically at consecutive G residues through electron transfer. Pterin-6-carboxylic acid bind to the active site of phosphodiesterase 5 with the binding energy value of -7.1 and 2.05A° 2.23A° when compared with other compound found in the plant. In silico studies hypothesized that pterin-6-carboxylic acid can be an inhibitory agent for PDE5 protein which could be a potential drug candidate for the treatment of erectile dysfunction.
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Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA, 6-Carboxypterin, PDE5, Pterine-6-carboxylic acid

Compound Identifiers

PubChem CID

135403803