PROTAC pan-KRAS degrader-1

SKU: orb3135627

Description

PROTACpan-KRAS degrader-1 is a pan-KRAS PROTAC degrader that targets multiple KRAS mutants, including G12D, G12C, G12V, and G13D. It effectively degrades the KRAS mutant (G12D) in AGS cells, with a DC50 of 1.1 nM and a Dmax of 95%. This compound can be used in studies of diseases caused by KRAS mutations or amplifications, particularly in cancers such as breast, bladder, and gastric cancer.

Research Area

Signal Transduction

Key Properties

• CAS Number: 3043908-63-7
• MW: 1192.38
• Formula: C₆₃H₇₁F₂N₁₃O₇S
• SMILES: C(C1(COC=2N=C(C3=C(N2)C(F)=C(N=C3)C=4C5=C(C=C(O)C4)C=CC(F)=C5CC)N6C[C@](C)(O)CCC6)CC1)N7CCC(OC=8C=NC(=CN8)C9=CN([C@H](C(=O)N%10[C@H](C(N[C@@H](C)C%11=CC=C(C=C%11)C%12=C(C)N=CS%12)=O)C[C@@H](O)C%10)C(C)C)N=N9)CC7
• Target: PROTACs,Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PROTACs,Ras