PROTAC MNK1 degrader-1

SKU: orb3028069

Description

ROTACMNK1degrader-1 is a selective MNK1 PROTAC degrader with a DC50 of 11.92 nM and a Dmax greater than 96% in MV4-11 cells. It significantly reduces p-eIF4E levels with an IC50 of 22.07 nM, induces apoptosis, and causes cell cycle arrest at the G1 phase. This compound exhibits potent antitumor activity, demonstrating strong anti-leukemic effects in MV4-11 xenograft mouse models with acceptable drug safety.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• MW: 670.78
• Formula: C₃₅H₃₈N₆O₆S
• SMILES: O=C(C1CCN(C(CCCCCC(NC2=C(CN(C3C(NC(CC3)=O)=O)C4=O)C4=CC=C2)=O)=O)CC1)NC(S5)=NC=C5C6=CC=CC=C6
• Target: Apoptosis,PERK,PROTACs,MNK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,PERK,PROTACs,MNK