PROTAC K-Ras Degrader-6

SKU: orb2802159

Description

Compound 102 is a cereblon-based PROTAC that potently degrades pan-KRAS isoforms with a DC50 below 100 nM. This degrader demonstrates anticancer activity and is a valuable tool for investigating KRAS-driven cancers in both in vitro and in vivo research models.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 3052745-46-4
• MW: 1022.19
• Formula: C₅₇H₆₅F₂N₁₁O₅
• SMILES: O=C1NC(=O)C(N2C(=O)N(C3=CC(=CC=C32)N4CCC(CN5CCC(CC5)CC6CCN(CCOC7=NC8=C(F)C(=NC=C8C(=N7)N9CC%10NC(C9)CC%10)C=%11C=C(O)C=C%12C=CC(F)=C(C#C)C%12%11)CC6)CC4)C)CC1
• Target: Antibacterial,PROTACs,Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172129372