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PROTAC IRAK4 degrader-12

SKU: orb2695284

Description

PROTAC IRAK4 degrader-12 is a potent, cereblon-based degrader achieving >100% IRAK4 degradation in K562 cells with a 4.87 nM IC50. This tool compound is valuable for studying IRAK4's role in oncology and immunology through in vitro degradation experiments.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number2919995-09-6
MW926.41
FormulaC46H50ClF2N11O6
SMILESN(C(CN1CCN(C[C@H]2CC[C@@H](CC2)N3C=C(NC(=O)C=4N=C(OC4)C=5C=C(NCC6CC6)N=CC5)C(C(F)F)=N3)CC1)=O)C7=C8C(C=9C(=NOC9C=C8)C%10C(=O)NC(=O)CC%10)=CC=C7.Cl
TargetIRAK,PROTACs

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

Protocol Information