PROTAC IRAK4 degrader-12

SKU: orb2695284

Description

PROTAC IRAK4 degrader-12 is a potent, cereblon-based degrader achieving >100% IRAK4 degradation in K562 cells with a 4.87 nM IC50. This tool compound is valuable for studying IRAK4's role in oncology and immunology through in vitro degradation experiments.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2919995-09-6
• MW: 926.41
• Formula: C₄₆H₅₀ClF₂N₁₁O₆
• SMILES: N(C(CN1CCN(C[C@H]2CC[C@@H](CC2)N3C=C(NC(=O)C=4N=C(OC4)C=5C=C(NCC6CC6)N=CC5)C(C(F)F)=N3)CC1)=O)C7=C8C(C=9C(=NOC9C=C8)C%10C(=O)NC(=O)CC%10)=CC=C7.Cl
• Target: PROTACs,IRAK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172652660