PROTAC IRAK4 degrader-12

SKU: orb2695284

Description

PROTAC IRAK4 degrader-12, a Cereblon ligand-based PROTAC, induces a maximum degradation of IRAK4 in K562 cells at 108.46% with an IC50 value of 4.87 nM. (Structure Note: Pink, IRAK4 Inhibitor; Blue, E3; Black, linker.)

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2919995-09-6
• MW: 926.41
• Formula: C₄₆H₅₀ClF₂N₁₁O₆
• SMILES: N(C(CN1CCN(C[C@H]2CC[C@@H](CC2)N3C=C(NC(=O)C=4N=C(OC4)C=5C=C(NCC6CC6)N=CC5)C(C(F)F)=N3)CC1)=O)C7=C8C(C=9C(=NOC9C=C8)C%10C(=O)NC(=O)CC%10)=CC=C7.Cl
• Target: IRAK,PROTACs

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172652660