PROTAC FLT-3 degrader 4

SKU: orb2564707

Description

PROTACFLT-3 degrader 4 is an orally bioavailable, CRBN-recruiting PROTAC that selectively degrades FLT3-ITD mutant proteins via the ubiquitin-proteasome system. It demonstrates potent anti-leukemic activity in cellular models and is a valuable tool for investigating targeted protein degradation in FLT3-ITD mutant AML research, both in vitro and in vivo.

Research Area

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2956722-48-6
• MW: 736.79
• Formula: C₃₉H₄₁FN₈O₆
• SMILES: O=C1N(C(=O)C=2C1=CC(=CC2)N3CCC(CN4CCN(CC(NC=5C(C)=C(/C=C\6/C=7C(NC6=O)=CC=C(F)C7)NC5)=O)CC4)CC3)C8C(=O)NC(=O)CC8
• Target: FLT,Apoptosis,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

169086096