PROTAC FLT-3 degrader 1

SKU: orb1991263

Description

PROTAC FLT-3 degrader 1 is a potent, small molecule proteolysis-targeting chimera (PROTAC) that selectively degrades FLT-3-ITD with an IC50 of 0.6 nM. It demonstrates robust anti-proliferative effects in cellular assays and is a valuable chemical tool for investigating targeted protein degradation in acute myeloid leukemia (AML) research, both in vitro and in vivo.

Research Area

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2230826-81-8
• MW: 1020.23
• Formula: C₅₂H₆₁N₉O₉S₂
• SMILES: O(CCOCCOCCC(N[C@H](C(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1)C(C)(C)C)=O)C=4C=C5C(N6C(S5)=NC(=C6)C7=CC=C(NC(NC=8C=C(C(C)(C)C)ON8)=O)C=C7)=CC4
• Target: PROTACs,FLT,MEK,STAT,ERK,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

135172387