PROTAC ERα Degrader-10

SKU: orb2814406

Description

PROTAC ERα Degrader-10 (Compound 160a) is a potent, orally active small molecule that degrades ERα with low nM DC50 values in breast cancer cell lines. It has shown promising in vivo antitumor efficacy in mouse models, supporting its use in oncology research for studying ERα-driven cancers and targeted protein degradation.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2421260-43-5
• MW: 723.9
• Formula: C₄₅H₄₉N₅O₄
• SMILES: C(=C(/CC)\C1=CC=CC=C1)(\C2=CC=C(C=C2)N3CCC(CN4CCN(CC4)C=5C=C6C(=CC5)C(=O)N(C6)[C@@H]7C(=O)NC(=O)CC7)CC3)/C8=CC=C(O)C=C8
• Target: PROTACs,Estrogen Receptor/ERR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

146566288