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PROTAC EGFR degrader 15

SKU: orb3175217

Description

PROTACEGFRdegrader 15 is a bifunctional EGFR PROTAC degrader composed of Pomalidomide and Gefitinib. It facilitates EGFR degradation through ubiquitin-proteasome dependent proteolysis and autophagic-lysosomal pathways. Additionally, PROTACEGFRdegrader 15 targets ETFA to enhance ATP production. It significantly suppresses tumor growth in Gefitinib-resistant HCC-827 xenograft models.

Images & Validation

Key Properties

TargetATPase,PROTACs,EGFR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information