PROTAC EGFR degrader 13

SKU: orb3135751

Description

PROTACEGFRdegrader 13 (compound 106) is an EGFR PROTAC degrader with a DC50 of less than 0.1 μM. It demonstrates antiproliferative activity against Ba/F3-TEL-EGFR-T790M-L858R-C797S cells, with an IC50 of 15.6 nM. PROTACEGFRdegrader 13 is applicable in the research of EGFR-related diseases, such as cancer.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	2861227-35-0
MW	1004.91
Formula	C₄₉H₅₅BrN₁₁O₆P
SMILES	O=C1C2=CC=C(C=C2C(=O)N1C3C(=O)NC(=O)CC3)N4CCN(CC4)CC5CCN(C=6C=C(OC)C(=CC6C=7C=NN(C7)C)NC8=NC=C(Br)C(=N8)NC9=CC=C(C=C9P(=O)(C)C)C%10CC%10)CC5
Target	EGFR,PROTACs

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

EGFR,PROTACs

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