Procyanidin B3

SKU: orb1297525

Description

Procyanidin B3 is a naturally occurring dimeric procyanidin studied for its antioxidant properties. It is utilized in research areas such as cardiovascular health, neuroprotection, and metabolic syndrome, with applications in both in vitro assays and in vivo animal models.

Research Area

Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 23567-23-9
• MW: 578.52
• Purity: 99.71% (May vary between batches)
• Formula: C₃₀H₂₆O₁₂
• SMILES: O[C@H]1Cc2c(O)cc(O)c([C@H]3[C@H](O)[C@H](Oc4cc(O)cc(O)c34)c3ccc(O)c(O)c3)c2O[C@@H]1c1ccc(O)c(O)c1
• Target: TLR,Histone Acetyltransferase,Androgen Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.73 mM);DMSO:10 mg/mL (17.29 mM)

Bioactivity

• In Vitro:
  We observed that Procyanidin B3 inhibited H(2)O(2)-induced apoptosis in primary chondrocytes, suppressed H(2)O(2)- or IL-1 -induced nitric oxide synthase (iNOS) production, and prevented IL-1 -induced suppression of chondrocyte differentiation marker gene expression in primary chondrocytes. Moreover, Procyanidin B3 treatment enhanced the early differentiation of ATDC5 cells. To examine whether Procyanidin B3 prevents cartilage destruction in vivo, OA was surgically induced in C57BL/6J mice followed by oral administration of Procyanidin B3 or vehicle control. Daily oral Procyanidin B3 administration protected articular cartilage from OA and prevented chondrocyte apoptosis in surgically-induced OA joints. Furthermore, Procyanidin B3 administration prevented heterotopic cartilage formation near the surgical region. iNOS protein expression was enhanced in the synovial tissues and the pseudocapsule around the surgical region in OA mice fed a control diet, but was reduced in mice that received Procyanidin B3. Together, these data indicated that in the OA model, Procyanidin B3 prevented OA progression and heterotopic cartilage formation, at least in a part through the suppression of iNOS.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Androgen Receptor, HistoneAcetyltransferase, histone acetyltransferase, Histone Acetyltransferase, IL Receptor, Inhibitor, HAT, HATs, inhibit, NOS, Procyanidin B 3, Procyanidin B3, Procyanidin B-3

Compound Identifiers

PubChem CID

146798