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PRMT5/EGFR-IN-1

SKU: orb3133932

Description

PRMT5/EGFR-IN-1 (Compound 10p) is an orally active dual inhibitor targeting PRMT5 and EGFR, with IC50 values of 15.47 μM and 19.31 μM, respectively. It demonstrates antiproliferative activity against the A549, MCF7, HeLa, and MDA-MB-231 cell lines. This compound also exhibits favorable pharmacokinetic (PK) and pharmacodynamic (PD) properties in vivo and significantly inhibits the growth of MCF7 orthotopic xenograft tumors.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Epigenetics & Chromatin; Cell Biology, Signal Transduction

Images & Validation

Key Properties

FormulaC27H22F6N2O2
TargetEGFR,Histone Methyltransferase

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information

PRMT5/EGFR-IN-1 (orb3133932)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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