Pristinamycin IA

SKU: orb1309217

Description

Pristinamycin IA (Mikamycin B) is a cyclic peptidomacrolactone antibiotic and a known substrate for the P-glycoprotein efflux pump. It is used in research to study antibiotic mechanisms, bacterial resistance, and P-gp-mediated multidrug resistance in both in vitro and in vivo models.

Research Area

Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3131-03-1
• MW: 866.96
• Purity: 97.92% (May vary between batches)
• Formula: C₄₅H₅₄N₈O₁₀
• SMILES: [H][C@@]12CCCN1C(=O)[C@H](CC)NC(=O)[C@@H](NC(=O)c1ncccc1O)[C@H](C)OC(=O)[C@@]([H])(NC(=O)[C@]1([H])CC(=O)CCN1C(=O)[C@H](Cc1ccc(cc1)N(C)C)N(C)C2=O)c1ccccc1
• Target: P-gp,Antibacterial,Antibiotic
• Solubility: DMSO:30 mg/mL (34.6 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (2.88 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antibiotic, Bacterial, inhibit, macrolactone, Mikamycin B, Mikamycin IA, Inhibitor, vinblastine, Pgp, P-glycoprotein, Pristinamycin IA, ribosome

Compound Identifiers

PubChem CID

155859182