Pramocaine hydrochloride

SKU: orb1310591

Description

Pramocaine hydrochloride (Pramoxine HCl) is a topical anesthetic compound used in research for its antipruritic properties. It is applied in dermatological studies to investigate local anesthesia and itch relief mechanisms in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 637-58-1
• MW: 329.86
• Purity: 99.61% (May vary between batches)
• Formula: C₁₇H₂₇NO₃·HCl
• SMILES: Cl.CCCCOc1ccc(OCCCN2CCOCC2)cc1
• Target: Sodium Channel,Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.06 mM);DMSO:75 mg/mL (227.37 mM)

Bioactivity

• In Vivo:
  Pramoxine is frequently used in conjunction with Hydrocortisone, Colloidal oatmeal, Menthol, and Petrolatum.
• In Vitro:
  When administered to canines exhibiting dyspnea (breathing difficulty) and tremors, Pramoxine elicited specific changes in skin temperature at which the activation and suppression of panting and shivering occur. These changes are thought to be mediated by peripheral nerves that control the terminal mechanisms of thermoregulation. In studies on guinea pig ileum, Pramoxine (1.7 mM) demonstrated a lesser reduction in response to Substance P compared to its effects on responses to acetylcholine, BaCl2, and histamine. Pramoxine has been identified as having anesthetic inhibitory potency, with a pKa of 6.4 in guinea pig ileum.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Pramocaine hydrochloride, Pramocaine Hydrochloride, Pramoxine, Pramoxine HCl, Pramoxine hydrochloride, Pramoxine Hydrochloride, Pramocaine, SodiumChannel, Sodium Channel

Compound Identifiers

PubChem CID

73957