Pozelimab Antibody

SKU: orb1980327

Description

Pozelimab (REGN 3918) is a humanized anti-C5 monoclonal antibody used in research. It is applied in preclinical studies to investigate complement-mediated disorders, with utility demonstrated in both in vitro assays and in vivo animal models for conditions like paroxysmal nocturnal hemoglobinuria.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 2096328-94-6
• MW: 144.78 kDa
• Purity: 95.00%
• Target: Complement System

Bioactivity

• In Vivo:
  Pozelimab (5 or 10 mg/kg, injected subcutaneously) has a half-life of 12.9-13.3 days in cynophilic monkeys. Pozelimab (15 mg/kg, injected subcutaneously) showed prolonged pharmacokinetics and pharmacodynamics in both mice and cynophagous monkeys, and blocked complement mediated in vitro hemolysis activity for at least 35 days.
• In Vitro:
  The Kd values of Pozelimab binding to human C5 and cyborg monkey C5 were 262 pM and 8.55 nM, and the IC50 values were 2.8 nM and 20 nM, respectively. Pozelimab blocks alternative pathway (AP) -mediated hemolysis in normal and cynomolophoric monkeys with IC50 values of 26 and 8.9 nM, respectively.

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

REGN 3918, REGN3918

Quick Database Links

Gene Symbol

Complement System