POSH-IN-1

SKU: orb2695620

Description

POSH-IN-1 (Compound 108) is a small molecule inhibitor of the POSH E3 ubiquitin ligase, exhibiting an IC50 of 900 nM. This compound serves as a research tool for investigating POSH-related pathways in virology, oncology, and neurobiology, with utility in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 328960-84-5
• MW: 289.28
• Purity: 99.29%
• Formula: C₁₄H₈FNO₃S
• SMILES: O=C1SC(=CC=2OC(=CC2)C=3C=CC(F)=CC3)C(=O)N1
• Target: HIV Protease,DUB
• Solubility: DMSO:40 mg/mL (138.27 mM)

Bioactivity

• Target IC50:
  POSH:900 nM
• In Vitro:
  POSH-IN-1(compound 108) inhibited the ubiquitin ligase activity of POSH with an IC₅₀ of 900 nM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

2844288