Polyethylene glycol 12-hydroxystearate

SKU: orb1306982

Description

Solutol HS-15, a nonionic surfactant composed of polyethylene glycol 12-hydroxystearate, is widely used as a permeability enhancer in pharmaceutical research. It facilitates drug delivery by improving solubility and membrane penetration in both in vitro cellular assays and in vivo animal studies for poorly water-soluble compounds.

Key Properties

• CAS Number: 61909-81-7
• MW: 361.567
• Purity: 98.00% (May vary between batches)
• Formula: (C₂H₄O)nC₁₈H₃₆O₃
• SMILES: N.CCCCCCC(O)CCCCCCCCCCC(=O)OCCO
• Target: Others
• Solubility: DMSO:262 mg/mL;Ethanol:100 mg/mL;H2O:25 mg/mL

Bioactivity

• In Vitro:
  Polyethylene glycol 12-hydroxystearate promotes the apical-to-basolateral translocation of a model protein (insulin) across Calu-3 monolayers when applied at 37°C. Furthermore there is no statistically significant increase in insulin permeability in the presence of Polyethylene glycol 12-hydroxystearate, relative to the respective control, at 4°C. Polyethylene glycol 12-hydroxystearate treated cells show a statistically significant increase in permeability towards lower molecular weight permeants (5 to 22 kDa) and an absence of a statistically significant increase in permeability of proteins with larger molecular weight, namely albumin and IgG (P>0.05 relative to control).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, HS-15, Inhibitor, Polyethylene glycol 12hydroxystearate, Polyethylene glycol 12-hydroxystearate, Polyethylene glycol 12 hydroxystearate, Solutol, Solutol HS-15

Compound Identifiers

PubChem CID

137699175