PMX-53 TFA

SKU: orb1980131

Description

PMX-53 is a potent C5a receptor antagonist (IC50 = 0.3 µM) that inhibits C5a-induced MPO release in human PMNs in vitro. It demonstrates in vivo efficacy by reducing inflammation in rat Arthus reaction and Huntington's disease models, and attenuates atherosclerosis in ApoE-/- mice.

Research Area

Immunology & Inflammation; Stem Cell & Developmental Biology

Key Properties

• CAS Number: 514814-99-4
• MW: 896.09
• Formula: C₄₇H₆₅N₁₁O₇.XCF₃COOH
• SMILES: O=C([C@H](NC([C@@]1([H])N(CCC1)C([C@H](CCCNC([C@@H](NC2=O)CCCNC(N)=N)=O)NC([C@@H](NC(C)=O)CC3=CC=CC=C3)=O)=O)=O)CC4CCCCC4)N[C@H]2CC5=CNC6=CC=CC=C56.OC(C(F)(F)F)=O

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171361269