PKR-IN-C16

SKU: orb1307866

Description

PKR-IN-C16 is a selective ATP-competitive inhibitor of the protein kinase PKR, blocking its autophosphorylation with an IC50 of ~200 nM. It alleviates PKR-mediated translational blockade and protects neuronal cells from ER stress-induced damage, making it a valuable tool for studying neuroprotection and stress response pathways in vitro.

Research Area

Cell Biology

Key Properties

• CAS Number: 608512-97-6
• MW: 268.29
• Purity: 99.48% (May vary between batches)
• Formula: C₁₃H₈N₄OS
• SMILES: O=C1Nc2ccc3ncsc3c2\C1=C\c1cnc[nH]1
• Target: Others,Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.73 mM);DMSO:6.1 mg/mL (22.74 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PKR, PKRINC16, PKR-IN-C16, PKR-IN-C-16, PKR IN C16, SH-SY5Y, Inhibitor, inhibit, acute brain lesions, Apoptosis

Compound Identifiers

PubChem CID

6490494