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C16

SKU: orb1307866

Description

PKR-IN-C16 is a selective ATP-competitive inhibitor of the protein kinase PKR, blocking its autophosphorylation with an IC50 of ~200 nM. It alleviates PKR-mediated translational blockade and protects neuronal cells from ER stress-induced damage, making it a valuable tool for studying neuroprotection and stress response pathways in vitro.

Research Area

Cell Biology, Neuroscience

Images & Validation

Key Properties

CAS Number608512-97-6
MW268.30
Purity>98%
FormulaC13H8N4OS
SMILESO=C1Nc2ccc3ncsc3c2\C1=C\c1cnc[nH]1
TargetKinase
SolubilitySoluble in DMSO (up to 15 mg/ml, with warming).

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PKR, PKRINC16, PKR-IN-C16, PKR-IN-C-16, PKR IN C16, SH-SY5Y, Inhibitor, inhibit, acute brain lesions, Apoptosis

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Key Properties

No computed properties available.

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Protocol Information

C16 (orb1307866)

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5 mg
$ 210.00
25 mg
$ 460.00
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