Pimobendan

SKU: orb1307669

Description

Pimobendan

Research Area

Metabolism Research

Key Properties

• CAS Number: 74150-27-9
• MW: 334.37
• Purity: 99.91%
• Formula: C₁₉H₁₈N₄O₂
• SMILES: CC1C(C=2C=C3C(N=C(N3)C4=CC=C(OC)C=C4)=CC2)=NNC(=O)C1
• Target: PDE
• Solubility: Ethanol:5 mg/mL (14.95 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:55 mg/mL (164.49 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.98 mM)

Bioactivity

• Target IC50:
  PDE3:0.32 μM
• In Vivo:
  When administered to human atrial cells, Pimobendan (100 μM) increased the L-type calcium current by 250.4% (EC50: 1.13 μM). Its effect on rabbit atrial cells was significantly lower, resulting in a 67.4% increase in ICa(L). Pimobendan exhibits selective inhibitory action on isolated PDE III in guinea pig myocardium (IC50: 0.32 μM), with much higher IC50s for PDE I and PDE II (>30 μM). It also inhibits cAMP-PDE III activity (IC50: 2.4 μM) and induces a positive inotropic effect on isolated guinea pig papillary muscles (EC50: 6.0 μM), partially due to its selective inhibition of myocardial PDE III.
• In Vitro:
  Compared to the control group, Pimobendan (1 mg/kg) significantly reduced the permeability of cardiomyocytes and also decreased the levels of TNF-α and IL-1β within the chamber without affecting myocardial nerves, heart weight, and body weight. In a mouse model of EMC virus-induced myocarditis, Pimobendan contributed to an extension of lifespan. The final survival rate was significantly increased from 33.6% (control group) to 53.3% (0.1 mg/kg) or 66.7% (1 mg/kg). Additionally, Pimobendan inhibited the expression of inducible nitric oxide synthase genes in the heart, thereby reducing the content of nitric oxide within the heart.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

UD-CG 115, UD-CG 115 BS, UD-CG115, UD-CG-115, Pimobendane, Pimobendan, Phosphodiesterase (PDE), phosphodiesterase, Acardi, inhibit, PDE3, Inhibitor

Compound Identifiers

PubChem CID

4823