Phytic acid

SKU: orb1304788

Description

Phytic acid

Research Area

Metabolism Research

Key Properties

• CAS Number: 83-86-3
• MW: 660.04
• Purity: 99.93%
• Formula: C₆H₁₈O₂₄P₆
• SMILES: O(P(=O)(O)O)[C@H]1[C@@H](OP(=O)(O)O)[C@@H](OP(=O)(O)O)[C@H](OP(=O)(O)O)[C@@H](OP(=O)(O)O)[C@@H]1OP(=O)(O)O
• Target: Xanthine Oxidase,Endogenous Metabolite
• Solubility: DMSO:247 mg/mL (374.22 mM)

Bioactivity

• In Vivo:
  Phytic acid has a neuroprotective effect in MPTP-induced PD model and the neuroprotection is correlated with its anti-inflammatory effect which may be associated with suppression of pathways that involved in NF-κB and p-ERK. Phytic acid significantly inhibits MPTP-induced dopaminergic cell loss in the substantia nigra (SN). Moreover, using immunohistochemistry method and quantitative polymerase chain reaction (qPCR), microglial activation and inducible nitric oxide synthase (iNOS) are found to be markedly repressed by phytic acid.
• In Vitro:
  Phytic acid, a major phosphorus storage compound of most seeds and cereal grains, contributes about 1 to 7% of their dry weight. It may account for more than 70% of the total kernel phosphorus. Phytic acid has the strong ability to chelate multivalent metal ions, especially zinc, calcium, and iron. The binding can result in very insoluble salts that are poorly absorbed from the gastrointestinal tract, which results in poor bioavailability of minerals. Phytic acid is also considered to be a natural antioxidant and is suggested to have potential functions of reducing lipid peroxidation and as a preservative in foods. Phytic acid inhibits the formation of uric acid from xanthine with an IC50 of about 30 mM. The generation of the superoxide is greatly affected by phytic acid; the IC50 is about 6 mM, indicating that the superoxide generating domain of XO is more sensitive to phytic acid. There has been observed an inhibition of tumor growth and induction of cell differentiation in the presence of phytic acid in a few cancer cell lines including colon, nipple, breast, prostate, cervix, liver, pancreas, melanoma and glioblastoma.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Endogenous Metabolite, myo-Inositol, hexakis(dihydrogen phosphate), inhibit, Inhibitor, Inositol, inositol polyphosphate, inositol hexakisphosphate, Inositol hexaphosphate, Inositol Hexaphosphate, EndogenousMetabolite, Fytic Acid, XanthineOxidase, Xanthine Oxidase, Phytic acid

Compound Identifiers

PubChem CID

890