Phosphodiesterase-IN-2

SKU: orb3134302

Description

Phosphodiesterase-IN-2 (Compound C7) is an orally active and selective inhibitor of phosphodiesterase 10A (PDE10A), with an IC50 of 11.9 nM. It enhances hepatic microsomal stability and reduces blood-brain barrier permeability. Phosphodiesterase-IN-2 exhibits favorable pharmacokinetic properties in mouse models and can alleviate isoprenaline-induced cardiac hypertrophy.

Key Properties

• CAS Number: 3047610-96-5
• MW: 584.59
• Formula: C₃₂H₂₇F₃N₆O₂
• SMILES: O=C(C1=CC(=NC=2C=CC=CC21)COC3=CC=C(C=C3)N4N=C(C=C4C=5C=CN=C(C5)C)C(F)(F)F)N6CC7(CNC7)C6
• Target: PDE

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PDE