Phospho-JAK2/3 (Tyr966/939) Antibody

• Catalog Number: orb1730659
• Category: Antibodies
• Description: Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: ELISA, WB
• Reactivity: Human, Mouse, Rat
• Isotype: Rabbit IgG
• Immunogen: Synthesized Phospho peptide derived from human JAK2/3.at AA range: T966
• Dilution range: WB: 1/500-1/1000; ELISA: 1/10000
• Conjugation: Unconjugated
• MW: Calculated MW: 131 kDa; Observed MW: 120-130 kDa
• Entrez: 3718, 3717
• UniProt ID: P52333, O60674
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Buffer/Preservatives: Liquid in PBS containing 50% glycerol, 0.5% rAlbumin and 0.02% sodium azide, pH 7.3.
• Alternative names: Tyrosine-protein kinase JAK2/JAK3 (EC 2.7.10.2; Ja
• Note: For research use only
• Expiration Date: 12 months from date of receipt.