Phosalone

SKU: orb1301443

Description

Phosalone is an organophosphate insecticide and acaricide. It is used in agricultural research to study acetylcholinesterase inhibition and is applicable in both in vitro enzyme assays and in vivo toxicological investigations on pest species.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 2310-17-0
• MW: 367.81
• Purity: 98.45% (May vary between batches)
• Formula: C₁₂H₁₅ClNO₄PS₂
• SMILES: C(SP(OCC)(OCC)=S)N1C=2C(OC1=O)=CC(Cl)=CC2
• Target: Parasite
• Solubility: DMSO:50 mg/mL (135.94 mM)

Bioactivity

• In Vivo:
  Phosalone (PLN) as a key member of OPs, to induce senescence in rat embryonic fibroblast (REF) cells and to demonstrate the beneficial effects of the known antioxidant ellagic acid (EA) in diminishing the PLN-induced toxic effects, the levels of cell viability, oxidative stress markers, inflammatory cytokines, telomerase activity, and the expression of the genes related to senescence were investigated. This accounts for the mechanistic approval of the role of OPs in induction of senescence in rat fibroblasts. Incorporation of EA diminished PLN toxicity mainly through suppression of p38 and p53 at gene and protein levels, and tempered the inflammation factors (TNF-α, IL-1β, IL-6 and NF-κB), which further affected cell division.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Parasite, inhibit, Inhibitor, Phosalone

Compound Identifiers

PubChem CID

4793