PGD97

SKU: orb2813669

Description

PGD97 is a potent, selective cyclic peptide inhibitor of the CAL-CFTR interaction (KD = 6 nM) with >130-fold selectivity over NHERF1/2. It stabilizes F508del-CFTR at the plasma membrane, enhancing channel function in cystic fibrosis research models, applicable for in vitro and ex vivo mechanistic studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• Target: CFTR,Chloride channel
• CAS Number: 2717490-36-1
• MW: 1643.01
• Formula: C₇₄H₁₁₁N₂₃O₁₄S₃
• SMILES: C(C=1C=2C(SC1)=CC=CC2)[C@H]3C(=O)N4[C@](C(=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@@](C)(C)C)C(O)=O)=O)CCCNC(=N)N)=O)[C@@H](C)O)=O)C(C)(C)SSC[C@H](NC(C)=O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC5=CC6=C(C=C5)C=CC=C6)C(=O)N3)(CCCC4)[H]

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

162671383