PFM39

SKU: orb1691830

Description

PFM39 is a Mirin analog and selective MRE11 exonuclease inhibitor that extends mitotic duration. It suppresses homologous recombination (HR) and can counteract DNA repair deficiencies resulting from EXO1 or BLM loss, making it a valuable tool for studying DNA damage response in cellular models.

Research Area

Cell Biology

Key Properties

• CAS Number: 1310744-67-2
• MW: 219.26
• Purity: 98.98% (May vary between batches)
• Formula: C₁₀H₉N₃OS
• SMILES: NC1=NC(=O)\C(S1)=C\c1ccc(N)cc1
• Target: Endonuclease,Others
• Solubility: DMSO:80 mg/mL (364.86 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (15.05 mM)

Bioactivity

• In Vitro:
  PFM39 (50 μM), as a MRE11 endonuclease inhibitor, effectively inhibits homologous recombination (HR) without significantly increasing non-homologous end joining (NHEJ).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Endonuclease, PFM39, PFM-39, PFM 39

Compound Identifiers

PubChem CID

53363864