PF-573228

SKU: orb1306782

Description

PF-573228

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 869288-64-2
• MW: 491.49
• Purity: 98.86%
• Formula: C₂₂H₂₀F₃N₅O₃S
• SMILES: CS(=O)(=O)c1cccc(CNc2nc(Nc3ccc4NC(=O)CCc4c3)ncc2C(F)(F)F)c1
• Target: Apoptosis,FAK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.07 mM);DMSO:25 mg/mL (50.87 mM)

Bioactivity

• Target IC50:
  FAK:4 nM
• In Vivo:
  PF 573228 IC50 30-500 nM) inhibited FAK Tyr397 phosphorylation in REF52 cells, PC3 cells, SKOV-3 cells, and L3.6p1 and F-G, MDCK cells.PF 573228 (1 μM) inhibited FAK phosphorylation but did not inhibit cell growth or induce apoptosis.
• Cell Research:
  Growth assays are performed by seeding 1 × 104 REF52 or PC3 cells/well of a 24-well plate in triplicate 24 h prior to daily treatment wit the indicated concentration of Each inhibitor for 3 days. Subsequently the cells are Harvested and counted.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Apoptosis, Inhibitor, FAK, Focal adhesion kinase, inhibit, PF 573228, PF573228, PF-573228, PTK2 protein tyrosine kinase 2, PTK2

Compound Identifiers

PubChem CID

11612883