PF-4618433

SKU: orb1704802

Description

PF-4618433 is a potent and selective small molecule inhibitor of PYK2 (PTK2B) that promotes osteogenic differentiation. It is a valuable research tool for studying bone biology, with demonstrated activity in both cellular assays and in vivo models of bone formation.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1166393-85-6
• MW: 445.52
• Purity: 99.95% (May vary between batches)
• Formula: C₂₄H₂₇N₇O₂
• SMILES: O=C(NC1=CC(=NN1)COC=2C=NC=CC2)NC3=CC(=NN3C4=CC=C(C=C4)C)C(C)(C)C
• Target: PYK2
• Solubility: DMSO:80 mg/mL (179.57 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.41 mM)

Bioactivity

• Target IC50:
  PYK2:637 nM
• In Vitro:
  PF-4618433 is a PYK2 inhibitor with an IC50 of 637 nM. PF-4618433 promotes bone formation in human mesenchymal stem cell (hMSC) cultures. PF-4618433 (0-0.3 μM, 24h) significantly increased the proliferative activity of osteoblasts and promoted the differentiation from immature mineralized osteoblasts to mature osteoblasts.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PF 4618433, PF4618433, PF-4618433

Compound Identifiers

PubChem CID

25203958