PF-06456384 trihydrochloride

SKU: orb1983410

Description

PF-06456384 trihydrochloride is a potent and selective NaV1.7 inhibitor with an IC50 of 0.01 nM, functioning via direct protein-ligand binding. Designed for intravenous administration, it serves as a valuable research tool for investigating pain mechanisms in both in vitro and in vivo models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1834610-75-1
• MW: 829.18
• Purity: 99.16%
• Formula: C₃₅H₃₅Cl₃F₃N₇O₃S₂
• SMILES: N#CC1=CC(S(=O)(NC2=NC=NS2)=O)=CC=C1OC3=CC=C(C4=CC(C(F)(F)F)=CC=C4)C=C3C5=CC(CNCCC6CCNCC6)=NC=C5.Cl.Cl.Cl
• Target: Sodium Channel
• Solubility: DMSO:100 mg/mL (120.6 mM)

Bioactivity

• Target IC50:
  NaV1.7:0.01 nM

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PF06456384 trihydrochloride

Compound Identifiers

PubChem CID

140810431